Exosome Therapy

Exosomes are a relatively new therapy in the field of regenerative medicine and are showing great promise as the next frontier of cell therapy. Research has shown that cell-to-cell communication is vital to maintaining a healthy cellular environment. Exosomes play a vital role in the communication and rejuvenation of all the cells in our body (1), and can be used to treat a multitude of disorders such as:

  • Orthopedic diseases
  • Anti-aging
  • Sexual dysfunction
  • Neurological Disease
  • Autoimmune disorders
  • Chronic inflammatory disorders
  • And many more!

Benefits of Exosome Therapy

Reduces Inflammation

Inflammation is the body’s way of fighting harmful factors like infections. However, chronic inflammation can lead to DNA damage, tissue death, and internal scarring. Exosome therapy reduces overall inflammation by sending messages to inflamed cells to reset, repair, and regenerate.

Supports Metabolic Function

When metabolic functions slow down, issues like weight gain, lethargy, and poor muscle tone ensue. Exosome therapy re-energizes and reinvigorates your cells, helping them metabolize nutrients better and generate more energy. By recharging your metabolic function, it’s easier to lose weight, improve muscle tone and increase your energy levels.

Improves Brain Health

Exosome therapy targets brain cells and signals them to regenerate and repair, improving cognitive function in alertness, mental performance, and clarity. You’ll notice your concentration will improve and your learning capacity.

Reduces Chronic Pain

Unlike acute pain, chronic pain serves no beneficial role in the body and can negatively impact daily life. Exosome therapy targets the origin cells emitting inflammatory signals, influencing them to heal and regenerate. A reduction in inflammation reduces the chronic pain signals being sent to the brain, resulting in less pain overall.

Reverses Tissue Degeneration

Aging is caused by tissue death and damage, among other factors. While diet and exercise can slow down these processes, exosome therapy appears to reverse them. Exosomes effectively reverse tissue degeneration by instructing the tissue cells to regenerate, resulting in new tissue growth and healthy cell regeneration.

Boosts Immune Health

Healthy cells boost the body’s defense systems, making it difficult for infection and disease to set in. Degenerative diseases are the result of continuous deterioration of cells, affecting tissues or organs. While stem cells are usually responsible for the rejuvenation of the cells, external factors may hinder the stem cells from performing their function. Studies have shown that patients suffering from osteoarthritis benefit from exosome therapy (3,6).

Supporting the cells’ function with external exosomes provides new pieces of information to support the healing process by relaying information on how healthy cells are supposed to function and act.

The Science Behind Exosomes

Exosomes are extracellular vesicles released from cells, particularly mesenchymal stem cells. The nanoparticles act as shuttles for genetic information, such as m-RNA, cytokines, and proteins to other cells.

These nanoparticles facilitate cell-to-cell communication, transporting important regulators of information between close, as well as, distant cells. The information is carried from place to place with the purpose of telling cells how and when to react (2). These nanoparticles enter your cells and provide them with instructions on how a healthy young cell is supposed to function.

Age, chronic disease, environmental factors, and genetic disorders can interfere with how our stem cells communicate with other cells, thus disrupting the healing process.

Who May Benefit from Exosome Therapy?

The most common uses of exosomes currently are to treat orthopedic injuries and as part of an anti-aging regimen. The exosomes are either injected into the area in need of treatment, like the knee or given intravenously for anti-aging and other systemic treatments. The idea is that they will promote tissue repair.

Exosomes are reported to help regulate cellular processes within the body. Patients with Lyme disease, chronic inflammation, arthritis, autoimmune disease, and other chronic degenerative diseases have reported benefit from including exosomes in their treatment regimen (7).

Exosomes may also be beneficial as part of anti-aging therapy. Patients with degenerative joint disease, Parkinson’s disease, Rheumatoid Arthritis, and Alzheimer’s disease have also benefited from the use of exosomes (3,6).

How is Exosome Therapy Performed?

We utilize exosome therapy as part of a multimodal approach to your healing and anti-aging solution.  Exosome products are either given through an IV (intravenously) or are injected directly into the joint that needs repair.

Find Your Pain Solution

  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care
  • Studies Cited:
  • 1. Hernigou P, Bouthors C, Bastard C, Flouzat Lachaniette CH, Rouard H, Dubory A. Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study. Int Orthop. 2021 Feb;45(2):391-399. doi: 10.1007/s00264-020-04687-7. Epub 2020 Jul 2. PMID: 32617651.
  • 2.Prodromos, Chadwick & Finkle, Susan. (2020). Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis. Medicines. 7. 37. 10.3390/medicines7060037.
  • 3. Y.S. Kim, Y.J. Choi, S.W. Lee, O.R. Kwon, D.S. Suh, D.B. Heo, Y.G. Koh. Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study, Osteoarthritis and Cartilage, Volume 24, Issue 2, 2016, Pages 237-245, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2015.08.009.
  • 4. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. PMID: 24430407.
  • 5. Hernigou P, Flouzat Lachaniette CH, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop. 2014 Sep;38(9):1811-8. doi: 10.1007/s00264-014-2391-1. Epub 2014 Jun 7. PMID: 24913770.
  • 6. Centeno C, Fausel Z, Stemper I, Azuike U, Dodson E. A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis. Stem Cells Int. 2020;2020:5962354. Published 2020 Jan 30. doi:10.1155/2020/5962354
  • 7. Centeno CJ, Pitts JA, Al-Sayegh H, Freeman MD (2014) Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritisof the Hip; Treatment Registry Results for 196 Patients. J Stem Cell Res Ther 4: 242. doi:10.4172/2157-7633.1000242
  • 8. Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clin Med Insights Case Rep. 2018;11:1179547618791574. Published 2018 Aug 10. doi:10.1177/1179547618791574
  • 9. Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269-276. Published 2015 Jun 5. doi:10.2147/JPR.S80872
  • 10. Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. J Nat Sci Biol Med. 2014;5(2):389-391. doi:10.4103/0976-9668.136198
  • 11. Lin, Junhong. International Journal of Clinical Pharmacology and Therapeutics; Munich Vol. 56, Iss. 8, (Aug 2018): 366.
  • 12. Kothari SY, Srikumar V, Singh N. Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder. J Clin Diagn Res. 2017;11(5):RC15-RC18. doi:10.7860/JCDR/2017/17060.9895
  • 13. Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/20448192
  • 14. Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21422467
  • 15. Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. http://www.ncbi.nlm.nih.gov/pubmed/23825183
  • 16. Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. http://www.ncbi.nlm.nih.gov/pubmed/17099241
  • 17. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy: A Double-Blind, Randomized Controlled Trial. The American Journal of Sports Medicine. 2014;42(3):610-618. doi:10.1177/0363546513518416
  • 18. Akşahin, Ertuğrul, et al. “The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.6 (2012): 781-785.
  • 19. Ragab, Ehab Mohamed Selem, and Ahmed Mohamed Ahmed Othman. “Platelets rich plasma for treatment of chronic plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.8 (2012): 1065-1070.
  • 20. Doaa H. Ibrahim, Nagat M. El-Gazzar, Hanan M. El-Saadany, Radwa M. El-Khouly, Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings. The Egyptian Rheumatologist, Volume 41, Issue 2, 2019, Pages 157-161, ISSN 1110-1164, https://doi.org/10.1016/j.ejr.2018.06.004.
  • 21. Dadgostar, H., Fahimipour, F., Pahlevan Sabagh, A. et al. Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study. J Orthop Surg Res 16, 333 (2021). https://doi.org/10.1186/s13018-021-02470-x
  • 22. Begkas D, Chatzopoulos ST, Touzopoulos P, Balanika A, Pastroudis A. Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study. Cureus. 2020;12(1):e6583. Published 2020 Jan 7. doi:10.7759/cureus.6583
  • 23. ROSÁRIO, DAVI ARAÚJO VEIGA et al. COMPARISON BETWEEN CONCENTRATED BONE MARROW ASPIRATE AND CORTICOID IN GLUTEAL TENDINOPATHY. Acta Ortopédica Brasileira [online]. 2021, v. 29, n. 1 [Accessed 1 December 2021] , pp. 26-29. Available from: <https://doi.org/10.1590/1413-785220212901236828>. Epub 10 Mar 2021. ISSN 1809-4406. https://doi.org/10.1590/1413-785220212901236828.
  • 24. Tang, J.Z., Nie, M.J., Zhao, J.Z. et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res 15, 403 (2020). https://doi.org/10.1186/s13018-020-01919-9