Ozone Therapy in Miami

USA Sports Medicine Ozone Therapy

What is Ozone Therapy?

Ozone is a natural gas that forms in the atmosphere and serves as a vital filter and barrier to ultraviolet solar rays.  Did you know that Ozone also has medicinal uses? Whereas the oxygen we breathe is 2 combined oxygen molecules (O2), Ozone is 3 combined oxygen molecules (O3).

Medicinal Ozone therapy utilizes an Ozone generator to create a mixture of Oxygen and Ozone.  The Ozone Generator creates Ozone by passing pure oxygen through a high-voltage, high-frequency electrical discharge. This electrochemical reaction produces a gas mixture with concentrated Ozone.  The concentrated ozone and dosages used are adjusted and individualized to the pathology, patient, and the desired treatment.

The Ozone, when in contact with the organism, produces very important therapeutic chemical changes.  It is widely used as an adjuvant medical treatment in a wide range of diseases. It is also used as an anti-aging strategy, to improve athlete’s performance and to gain wellness and quality of life for all that want to achieve better health.

How Does Ozone Therapy Work?

Ozone is a highly oxidative and reactive gas that is considered as a stressor pro-drug to your body (a). At therapeutic concentrations, Medical Ozone can:

  1. Modulate your Immune System
  2. Activate your own antioxidant mechanisms
  3. Oxygenate your tissues
  4. Activate your metabolism
  5. Activate circulation
  6. Reduce inflammation in your body
  7. Increase energy production
  8. Induce the secretion of substances like endorphins, serotonin, and other neurotransmitters

The potential benefits of Medical Ozone Therapy and the science behind it

  1. Germicidal – Ozone has been found to have direct killing effects on viruses, fungi, and bacteria in the body (a,b,c).
  2. Anti-inflammatory – Ozone inhibits pro-inflammatory pathways in the body (d,e,f,i,j)
  3. Improved Oxygen metabolism – Ozone helps shift the oxygen-hemoglobin dissociation curve, allowing red blood cells to release oxygen more efficiently to tissues low in Oxygen content.  It also aids in red blood cell metabolism, elasticity, and blood flow.   There is a significant improvement in blood flow and oxygenation of ischemic tissues due to ozone treatment (g,h).
  4. Antioxidant – Ozone activates your body’s own antioxidant mechanisms (k)
  5. Immune Boosting – Ozone works through many different pathways to boost your body’s immune responses (d,e,k).

What can Ozone Therapy Treat?

Ozone therapy and dosing is individualized to the patient.  Depending on the condition treated, there are numerous routes and protocols to enable the patient back to their desired activity level.  These options will be discussed at your consultation with Dr. Poovendran to establish the most effective treatment for you.

  • Illness – Through its many biological functions, Ozone can help a patient recover more quickly from viral infections, bacterial infections, and fungal infections.  It does this by augmenting your immune system as well as killing pathogens directly.
  • Sports recovery – Through anti-inflammatory effects, oxygen delivery effects, and immune-boosting effects, Ozone therapy can help you during all phases of your training program, making workouts more effective, and recovery quicker.
  • Anti-Aging – Through anti-oxidant, oxygen delivery, and metabolic effects, Ozone therapy can help improve the quality of life in patients by making them feel better and more energetic
  • Health Maintenance – As part of a wellness routine, ozone therapy can be utilized to help patients feel more energetic, more alert, recover from activity faster, and fight off infections.
  • Arthritis Pain – Through anti-inflammatory effects as well as analgesic effects, ozone use has been shown to help patients with joint pain.

How is Ozone Therapy Performed?

At USA Sports Medicine, we use Medical Ozone in several different modalities.  Ozone can be injected directly into the tissue to facilitate healing and decrease pain.

We can combine it with Platelet Rich Plasma (PRP) Injections to augment its effects.

In other situations, it can be used in conjunction with a prolotherapy solution to decrease inflammation or facilitate healing (Prolozone).

Also, we perform major autohemotherapy, a powerful systemic treatment, where ozone is given intravenously (through an IV) after being mixed with the patient’s blood.

References

  1. Smith NL, Wilson AL, Gandhi J, Vatsia S, Khan SA. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017;7(3):212-219.
  2. Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011;2(1):66-70. doi:10.4103/0976-9668.82319
  3. Wentworth P Jr, McDunn JE, Wentworth AD, et al. Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation. Science. 2002;298(5601):2195–2199
  4. Re L, Martinez-Sanchez G, Bordicchia M, et al. Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result. Eur J Pharmacol. Nov 5 2014;742:158-162.
  5. Bocci V, Valacchi G. Nrf2 activation as target to implement therapeutic treatments. Front Chem 2015;3:4. Doi: 10.3389/fchem.2015.00004
  6. Ricevuti, G. Oxygen-ozone immunoceutical therapy in COVID-19 outbreak: facts and figures, [Ozone Therapy 2020; 5:9014]
  7. Sagai M, Bocci V. Mechanisms of action involved in ozone therapy: is healing induced via a mild oxidative stress? Med Gas Res 2011;1:29.
  8. Hernández F, Calunga JL, Turrent J, Menéndez S and Montenegro A. Ozone therapy effects on blood biomarkers and lung function of asthma patients. Arch Med Res 2005;36(5):549-554.
  9. Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, Ciccoli L, Valacchi G. NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicol Appl Pharmacol 2013;267:30-40.
  10. Schulz S, Ninke S, Watzer B, Nusing RM. Ozone induces synthesis of systemic prostacyclin by cyclooxygenase-2 dependent mechanism in vivo. Biochem Pharmacol 2012;83:506–513.
  11. Bocci V, Aldinucci C, Mosci F; Carraro F; Valacchi G. Ozonation of human blood induces a remarkable upregulation of heme oxygenase-1 and heat stress protein-70. Mediators Inflamm 2007;2007:26785.

Find Your Pain Solution

  • Spine
  • Shoulder
  • Elbow/Wrist/Hand
  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee
  • Hip
  • Ankle/Foot/Balance
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Spine
  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Ankle/Foot/Balance
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Elbow/Wrist/Hand
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Hip
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care

Schedule a Consultation with a USA Sports Therapy Specialist Today

Citations

  • Studies Cited:
  • 1. Hernigou P, Bouthors C, Bastard C, Flouzat Lachaniette CH, Rouard H, Dubory A. Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study. Int Orthop. 2021 Feb;45(2):391-399. doi: 10.1007/s00264-020-04687-7. Epub 2020 Jul 2. PMID: 32617651.
  • 2.Prodromos, Chadwick & Finkle, Susan. (2020). Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis. Medicines. 7. 37. 10.3390/medicines7060037.
  • 3. Y.S. Kim, Y.J. Choi, S.W. Lee, O.R. Kwon, D.S. Suh, D.B. Heo, Y.G. Koh. Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study, Osteoarthritis and Cartilage, Volume 24, Issue 2, 2016, Pages 237-245, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2015.08.009.
  • 4. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. PMID: 24430407.
  • 5. Hernigou P, Flouzat Lachaniette CH, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop. 2014 Sep;38(9):1811-8. doi: 10.1007/s00264-014-2391-1. Epub 2014 Jun 7. PMID: 24913770.
  • 6. Centeno C, Fausel Z, Stemper I, Azuike U, Dodson E. A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis. Stem Cells Int. 2020;2020:5962354. Published 2020 Jan 30. doi:10.1155/2020/5962354
  • 7. Centeno CJ, Pitts JA, Al-Sayegh H, Freeman MD (2014) Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritisof the Hip; Treatment Registry Results for 196 Patients. J Stem Cell Res Ther 4: 242. doi:10.4172/2157-7633.1000242
  • 8. Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clin Med Insights Case Rep. 2018;11:1179547618791574. Published 2018 Aug 10. doi:10.1177/1179547618791574
  • 9. Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269-276. Published 2015 Jun 5. doi:10.2147/JPR.S80872
  • 10. Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. J Nat Sci Biol Med. 2014;5(2):389-391. doi:10.4103/0976-9668.136198
  • 11. Lin, Junhong. International Journal of Clinical Pharmacology and Therapeutics; Munich Vol. 56, Iss. 8, (Aug 2018): 366.
  • 12. Kothari SY, Srikumar V, Singh N. Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder. J Clin Diagn Res. 2017;11(5):RC15-RC18. doi:10.7860/JCDR/2017/17060.9895
  • 13. Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/20448192
  • 14. Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21422467
  • 15. Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. http://www.ncbi.nlm.nih.gov/pubmed/23825183
  • 16. Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. http://www.ncbi.nlm.nih.gov/pubmed/17099241
  • 17. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy: A Double-Blind, Randomized Controlled Trial. The American Journal of Sports Medicine. 2014;42(3):610-618. doi:10.1177/0363546513518416
  • 18. Akşahin, Ertuğrul, et al. “The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.6 (2012): 781-785.
  • 19. Ragab, Ehab Mohamed Selem, and Ahmed Mohamed Ahmed Othman. “Platelets rich plasma for treatment of chronic plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.8 (2012): 1065-1070.
  • 20. Doaa H. Ibrahim, Nagat M. El-Gazzar, Hanan M. El-Saadany, Radwa M. El-Khouly, Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings. The Egyptian Rheumatologist, Volume 41, Issue 2, 2019, Pages 157-161, ISSN 1110-1164, https://doi.org/10.1016/j.ejr.2018.06.004.
  • 21. Dadgostar, H., Fahimipour, F., Pahlevan Sabagh, A. et al. Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study. J Orthop Surg Res 16, 333 (2021). https://doi.org/10.1186/s13018-021-02470-x
  • 22. Begkas D, Chatzopoulos ST, Touzopoulos P, Balanika A, Pastroudis A. Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study. Cureus. 2020;12(1):e6583. Published 2020 Jan 7. doi:10.7759/cureus.6583
  • 23. ROSÁRIO, DAVI ARAÚJO VEIGA et al. COMPARISON BETWEEN CONCENTRATED BONE MARROW ASPIRATE AND CORTICOID IN GLUTEAL TENDINOPATHY. Acta Ortopédica Brasileira [online]. 2021, v. 29, n. 1 [Accessed 1 December 2021] , pp. 26-29. Available from: <https://doi.org/10.1590/1413-785220212901236828>. Epub 10 Mar 2021. ISSN 1809-4406. https://doi.org/10.1590/1413-785220212901236828.
  • 24. Tang, J.Z., Nie, M.J., Zhao, J.Z. et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res 15, 403 (2020). https://doi.org/10.1186/s13018-020-01919-9