Stem Cell Therapy

USA Sports Medicine Stem Cells Therapy

What is Stem Cell Therapy?

Stem Cell therapy is a type of regenerative medicine treatment, aimed at healing your injuries by regenerating tissue.  Stem cells are found throughout your body and are working constantly to balance tissue breakdown and tissue regeneration. Without active stem cells, you would die as your body could not repair itself.

How Does Stem Cell Therapy Work?

Adult stem cells have several unique properties that make them different from your other cells.  Their most unique quality is that they can form new tissue types.  After an injury occurs, platelets are the first responders to the site and release signaling molecules called cytokines and healing proteins called growth factors.  This healing cascade stimulates local stem cells to activate, replicate, differentiate, and repair.

Stem Cell Therapy takes your stem cells from an area of relative abundance and injects them directly into an area of relative deficiency, allowing you to heal more effectively.

Stem Cell Therapy helps people with:

  • Stem Cell treatments have been shown to increase meniscus volume and repair some meniscus tears.  Especially effective in the absence of mechanical symptoms (locking/buckling etc) (4)
  • Has been shown to be superior to Exercise therapy alone (4)
  • Rotator Cuff Tears
    • Studies of full-thickness tears undergoing repair showed better healing (100% healing on MRI vs 67% for non-stem cell treated) and lower retear rates at 10 years (13% vs 56% re-torn) (5)
    • Compared with exercise therapy alone for partial rotator cuff tears, patients undergoing stem cell injection showed 89% at 2 years. Most follow up MRI showed healing of the rotator cuff (6
  • Shoulder Osteoarthritis
    • Patients with symptomatic rotator cuff tears and arthritis of the shoulder underwent stem cell procedure noticed a 48.8% improvement at 2 years (9)
  • Hip Osteoarthritis
    • Patients with hip arthritis, who were candidates for hip replacement experienced 36-50% improvement of their hip pain at 9 months follow up (7)
    • Patients who underwent a series of stem cell injections into the hip noticed 74% improvement of their symptoms 4 months following their first injection (8)
  • Knee Osteoarthritis
    • One of the most studied uses for stem cells.
    • A French study comparing patients with one knee replaced and stem cell treated knee showed that 70% of the patients preferred their knee which received stem cell therapy. (1)
    • Another recent study showed that patients who had stem cell injections into their knee, 97% were able to avoid knee replacement in the first year, and 87% had still avoided knee replacement at the two year follow up (2)
    • For patients with osteoarthritis undergoing stem cell injection, there was improvement in pain and function scores, as well as improvement seen on follow up MRI imaging. (3)
  • Lateral Epicondylitis/Tennis Elbow
    • Patients with tennis elbow experienced significant improvement in their pain following stem cell treatment (10)
  • Hip Bursitis
    • Stem cell injection with bone marrow aspirate provided better and longer lasting relief when compared to cortisone injection for hip bursitis (23)

What is the Procedure for Stem Cell Therapy Like?

The procedure starts with taking bone marrow from one of your pelvic bones.  This is not nearly as painful as it may sound!  The sample is then placed in a centrifuge that spins at a high speed, separating the stem cells and platelets from the other components of the sample. The concentrated stem cell sample is removed and then injected into the injured tissue. We use ultrasound and/or fluoroscopic guidance for pinpoint accuracy. High-quality living stem cells, containing powerful growth factors and cytokines, helps to jumpstart the healing process.  It has even been shown to improve the quality of healing when compared to normal healing.

Stem Cell Therapy is an effective treatment used for common orthopedic conditions. It can be extremely beneficial for injuries to a tendon, ligament, or cartilage because these structures have a poor blood supply. Structures that do not receive enough blood supply have a hard time healing because the healing nutrients found in the blood cannot make it to the injury site.  A high concentration of healing factors taken from the blood and injected into the injured area can significantly speed up the rate of which one recovers as well as the quality of healing.

Not All Stem Cell Treatments Are Considered Equal

There is much confusion and there are many doctors claiming they are using stem cells, when in fact, they are not.

Our procedures are backed by real, up-to-date science and we make sure each patient is getting the highest quantity and quality of regenerative components. Do not get fooled by others who use placenta, amniotic or umbilical cells and try to pass them off as active stem cells.  By using live cells from your own body, we deliver the most active cells to aid in the healing process.

Bone Marrow contains both mesenchymal stem cells (MSCs) as well as hematopoietic stem cells (HSCs).  Both of these Bone Marrow Stem Cells guide tissue healing through their communication with other cells in the region.  The HSCs form white blood cells, red blood cells, and blood vessels which help provide optimal conditions for tissue repair.  Due to their plasticity, they can form into other cells as well.  Additionally, they stimulate the release of additional stem cells from the local bone marrow, as well as releasing growth factors and cytokines to aid in healing.

What should I do to prepare for the procedure?

We recommend that you avoid any NSAIDs (ibuprofen, naproxen, diclofenac, meloxicam) for at least 4 days prior to your procedure.  It is best to avoid receiving a steroid injection in the weeks leading up to your procedure.  Stay hydrated and try to drink at least 60 oz of water a day in the 2-3 days prior to the procedure.

Find Your Pain Solution

  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care

Citations

  • Studies Cited:
  • 1. Hernigou P, Bouthors C, Bastard C, Flouzat Lachaniette CH, Rouard H, Dubory A. Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study. Int Orthop. 2021 Feb;45(2):391-399. doi: 10.1007/s00264-020-04687-7. Epub 2020 Jul 2. PMID: 32617651.
  • 2.Prodromos, Chadwick & Finkle, Susan. (2020). Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis. Medicines. 7. 37. 10.3390/medicines7060037.
  • 3. Y.S. Kim, Y.J. Choi, S.W. Lee, O.R. Kwon, D.S. Suh, D.B. Heo, Y.G. Koh. Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study, Osteoarthritis and Cartilage, Volume 24, Issue 2, 2016, Pages 237-245, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2015.08.009.
  • 4. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. PMID: 24430407.
  • 5. Hernigou P, Flouzat Lachaniette CH, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop. 2014 Sep;38(9):1811-8. doi: 10.1007/s00264-014-2391-1. Epub 2014 Jun 7. PMID: 24913770.
  • 6. Centeno C, Fausel Z, Stemper I, Azuike U, Dodson E. A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis. Stem Cells Int. 2020;2020:5962354. Published 2020 Jan 30. doi:10.1155/2020/5962354
  • 7. Centeno CJ, Pitts JA, Al-Sayegh H, Freeman MD (2014) Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritisof the Hip; Treatment Registry Results for 196 Patients. J Stem Cell Res Ther 4: 242. doi:10.4172/2157-7633.1000242
  • 8. Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clin Med Insights Case Rep. 2018;11:1179547618791574. Published 2018 Aug 10. doi:10.1177/1179547618791574
  • 9. Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269-276. Published 2015 Jun 5. doi:10.2147/JPR.S80872
  • 10. Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. J Nat Sci Biol Med. 2014;5(2):389-391. doi:10.4103/0976-9668.136198
  • 11. Lin, Junhong. International Journal of Clinical Pharmacology and Therapeutics; Munich Vol. 56, Iss. 8, (Aug 2018): 366.
  • 12. Kothari SY, Srikumar V, Singh N. Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder. J Clin Diagn Res. 2017;11(5):RC15-RC18. doi:10.7860/JCDR/2017/17060.9895
  • 13. Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/20448192
  • 14. Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21422467
  • 15. Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. http://www.ncbi.nlm.nih.gov/pubmed/23825183
  • 16. Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. http://www.ncbi.nlm.nih.gov/pubmed/17099241
  • 17. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy: A Double-Blind, Randomized Controlled Trial. The American Journal of Sports Medicine. 2014;42(3):610-618. doi:10.1177/0363546513518416
  • 18. Akşahin, Ertuğrul, et al. “The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.6 (2012): 781-785.
  • 19. Ragab, Ehab Mohamed Selem, and Ahmed Mohamed Ahmed Othman. “Platelets rich plasma for treatment of chronic plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.8 (2012): 1065-1070.
  • 20. Doaa H. Ibrahim, Nagat M. El-Gazzar, Hanan M. El-Saadany, Radwa M. El-Khouly, Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings. The Egyptian Rheumatologist, Volume 41, Issue 2, 2019, Pages 157-161, ISSN 1110-1164, https://doi.org/10.1016/j.ejr.2018.06.004.
  • 21. Dadgostar, H., Fahimipour, F., Pahlevan Sabagh, A. et al. Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study. J Orthop Surg Res 16, 333 (2021). https://doi.org/10.1186/s13018-021-02470-x
  • 22. Begkas D, Chatzopoulos ST, Touzopoulos P, Balanika A, Pastroudis A. Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study. Cureus. 2020;12(1):e6583. Published 2020 Jan 7. doi:10.7759/cureus.6583
  • 23. ROSÁRIO, DAVI ARAÚJO VEIGA et al. COMPARISON BETWEEN CONCENTRATED BONE MARROW ASPIRATE AND CORTICOID IN GLUTEAL TENDINOPATHY. Acta Ortopédica Brasileira [online]. 2021, v. 29, n. 1 [Accessed 1 December 2021] , pp. 26-29. Available from: <https://doi.org/10.1590/1413-785220212901236828>. Epub 10 Mar 2021. ISSN 1809-4406. https://doi.org/10.1590/1413-785220212901236828.
  • 24. Tang, J.Z., Nie, M.J., Zhao, J.Z. et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res 15, 403 (2020). https://doi.org/10.1186/s13018-020-01919-9