PRP Therapy

USA Sports Medicine Stem Cells Therapy

What is PRP?

PRP stands for platelet-rich plasma. Platelets are the components of your blood that are best known for blood clotting. Blood is made up of 55% plasma, 45% red blood cells, and about 1% white blood cells and platelets. Platelets also contain hundreds of proteins called growth factors, which are important in the healing of injuries. PRP is the separation of those platelets and plasma from the rest of the blood, which results in a high concentration of the platelets within the plasma, hence, platelet-rich plasma.

How Does PRP Work? / How do we enhance your body’s natural PRP?

PRP augments your body’s own healing potential and capacity.  After an injury occurs, platelets are the first responders to the site and release signaling molecules called cytokines and healing proteins called growth factors.  Cytokines are small proteins that allow your cells to “talk” to each other to optimize immune response and healing, whereas growth factors in the body do the work and heal damage. Next, white blood cells, which also release growth factors, are summoned to the injured area to help heal.

PRP takes a higher concentration of platelets and the growth factors circulating in your blood and delivers it right to the site of injury.

PRP helps people with:

  • Frozen Shoulder/Adhesive Capsulitis
    • PRP has shown to be better in at least 2 studies when compared to exercise alone (11,12)
  • Lateral Epicondylitis/Tennis Elbow
    • Multiple studies showing benefit when compared to cortisone injection (better and longer-lasting pain relief, heals and reorganizes tissue vs causing tissue degeneration) (13,14, 15)
  • Achilles Tendonitis/Tendinosis
    • Patients receiving PRP post-surgically after achilles surgery had decreased time to regain range of motion, and return to their activities (16)
  • Patellar Tendinosis/Tendinitis/Jumper’s Knee
    • Safer than cortisone injection, and when combined with eccentric exercises, better healing than eccentric exercises or dry needling alone (17)
  • Plantar Fasciitis
    • PRP is more durable and effective than Cortisone injection in multiple studies (18, 19)
  • Shoulder Impingement
    • Studies showing improved pain relief, at least for the first 6 months when compared to cortisone injection – a safer alternative to a cortisone injection. (20, 21)
  • Hip Bursitis
    • Patients treated with PRP for hip bursitis had better outcomes and longer lasting relief compared to patients receiving cortisone injection (22)
  • Knee Arthritis
    • PRP injection was superior in short and long term pain relief when compared to hyaluronic acid injections (24)

Studies showing improved pain relief, at least for the first 6 months when compared to cortisone injection – a safer alternative to a cortisone injection.

What Is The Procedure For PRP Like?

The procedure starts with a simple blood draw. The blood sample is then placed in a centrifuge that spins at a high speed, separating the platelets from the other components of whole blood. Concentrated platelets and white blood cells are removed and then are injected into the injured tissue. We use ultrasound and/or fluoroscopic guidance for pinpoint accuracy.

High concentration autologous PRP, containing powerful growth factors and cytokines, helps to jumpstart the healing process.  It has even been shown to improve the quality of healing when compared to normal healing.

Not all PRP procedures are equal 

We use a double spin process that creates a pure PRP and preserves the highest concentration of PRP. Our kits ensure that no outside agents can enter the blood once drawn from our patients, making our procedures better and safer.

What Should I Do To Prepare For The Procedure?

We recommend that you avoid any NSAIDs (ibuprofen, naproxen, diclofenac, meloxicam) for at least 4 days prior to your procedure. It is best to avoid receiving a steroid injection in the weeks leading up to your procedure as well. Stay hydrated and try to drink at least 60 oz of water a day in the 2-3 days prior to the procedure.

Find Your Pain Solution

  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Herniated Disc
  • Radiculopathy
  • Facet Joint Dysfunction
  • Stenosis
  • Muscle Stiffness/Tightness Headaches
  • Sacro-Iliac Joint Pain (SIJ)
  • Nerve Entrapment
  • Back Pain
  • Neck Pain
  • Post-Surgical Care
  • Shoulder Pain
  • Rotator Cuff Tear/Sprain
  • Biceps Tendonitis
  • Shoulder Labral Tear
  • Shoulder Impingement/Bursitis
  • Adhesive Capsulitis/Frozen Shoulder
  • Scapular Dyskinesia
  • AC Joint Separation
  • Stenosis
  • Post-Surgical Care
  • Shin Splints
  • Ankle Sprains
  • Plantar Fasciitis
  • Heel Spur
  • Turf Toe
  • Bunions
  • Falls
  • Achilles Tendonitis
  • Parkinson’s
  • Stroke
  • Lateral Epicondylitis (Tennis Elbow)
  • Medial Epicondylitis (Golfer’s Elbow)
  • Climber’s Fracture
  • Trigger Finger
  • Wrist Sprain
  • Wrist Fractures
  • Knee Pain
  • Total Knee Replacement
  • ACL Sprain/Tear
  • MCL Sprain/Tear
  • PCL Sprain/Tear
  • Meniscus Tear
  • Osteoarthritis
  • Osgood Schlatter’s
  • Jumper’s Knee
  • Patello-Femoral Pain Syndrome
  • IT Band Syndrome
  • Hamstring Strain
  • Osgood Schlatter’s
  • Quadriceps Strain
  • Baker’s Cyst
  • Osteoarthritis
  • Total Hip Replacement
  • Femoral-Acetabular Impingement (FAI)
  • Piriformis Syndrome
  • Hip Trochanteric Bursitis
  • Gluteus Medius Tear
  • Nerve Entrapment
  • Hip Labral Tear
  • Stenosis
  • Post-Surgical Care

Citations

  • Studies Cited:
  • 1. Hernigou P, Bouthors C, Bastard C, Flouzat Lachaniette CH, Rouard H, Dubory A. Subchondral bone or intra-articular injection of bone marrow concentrate mesenchymal stem cells in bilateral knee osteoarthritis: what better postpone knee arthroplasty at fifteen years? A randomized study. Int Orthop. 2021 Feb;45(2):391-399. doi: 10.1007/s00264-020-04687-7. Epub 2020 Jul 2. PMID: 32617651.
  • 2.Prodromos, Chadwick & Finkle, Susan. (2020). Autologous Biologic Treatment with Fat, Bone Marrow Aspirate and Platelet Rich Plasma Is an Effective Alternative to Total Knee Arthroplasty for Patients with Moderate Knee Arthrosis. Medicines. 7. 37. 10.3390/medicines7060037.
  • 3. Y.S. Kim, Y.J. Choi, S.W. Lee, O.R. Kwon, D.S. Suh, D.B. Heo, Y.G. Koh. Assessment of clinical and MRI outcomes after mesenchymal stem cell implantation in patients with knee osteoarthritis: a prospective study, Osteoarthritis and Cartilage, Volume 24, Issue 2, 2016, Pages 237-245, ISSN 1063-4584, https://doi.org/10.1016/j.joca.2015.08.009.
  • 4. Vangsness CT Jr, Farr J 2nd, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014 Jan 15;96(2):90-8. doi: 10.2106/JBJS.M.00058. PMID: 24430407.
  • 5. Hernigou P, Flouzat Lachaniette CH, Delambre J, Zilber S, Duffiet P, Chevallier N, Rouard H. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop. 2014 Sep;38(9):1811-8. doi: 10.1007/s00264-014-2391-1. Epub 2014 Jun 7. PMID: 24913770.
  • 6. Centeno C, Fausel Z, Stemper I, Azuike U, Dodson E. A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis. Stem Cells Int. 2020;2020:5962354. Published 2020 Jan 30. doi:10.1155/2020/5962354
  • 7. Centeno CJ, Pitts JA, Al-Sayegh H, Freeman MD (2014) Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritisof the Hip; Treatment Registry Results for 196 Patients. J Stem Cell Res Ther 4: 242. doi:10.4172/2157-7633.1000242
  • 8. Darrow M, Shaw B, Darrow B, Wisz S. Short-Term Outcomes of Treatment of Hip Osteoarthritis With 4 Bone Marrow Concentrate Injections: A Case Series. Clin Med Insights Case Rep. 2018;11:1179547618791574. Published 2018 Aug 10. doi:10.1177/1179547618791574
  • 9. Centeno CJ, Al-Sayegh H, Bashir J, Goodyear S, Freeman MD. A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. J Pain Res. 2015;8:269-276. Published 2015 Jun 5. doi:10.2147/JPR.S80872
  • 10. Singh A, Gangwar DS, Singh S. Bone marrow injection: A novel treatment for tennis elbow. J Nat Sci Biol Med. 2014;5(2):389-391. doi:10.4103/0976-9668.136198
  • 11. Lin, Junhong. International Journal of Clinical Pharmacology and Therapeutics; Munich Vol. 56, Iss. 8, (Aug 2018): 366.
  • 12. Kothari SY, Srikumar V, Singh N. Comparative Efficacy of Platelet Rich Plasma Injection, Corticosteroid Injection and Ultrasonic Therapy in the Treatment of Periarthritis Shoulder. J Clin Diagn Res. 2017;11(5):RC15-RC18. doi:10.7860/JCDR/2017/17060.9895
  • 13. Peerbooms JC, (2010) Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-Year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/20448192
  • 14. Gosens T, et al. (2011) Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis: a double-blind randomized controlled trial with 2-year follow-up. http://www.ncbi.nlm.nih.gov/pubmed/21422467
  • 15. Mishra A, et al. (2014) Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. http://www.ncbi.nlm.nih.gov/pubmed/23825183
  • 16. Sanchez M, et al. (2007) Comparison of surgically repaired Achilles tendon tears using platelet rich fibrin matrices. http://www.ncbi.nlm.nih.gov/pubmed/17099241
  • 17. Dragoo JL, Wasterlain AS, Braun HJ, Nead KT. Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy: A Double-Blind, Randomized Controlled Trial. The American Journal of Sports Medicine. 2014;42(3):610-618. doi:10.1177/0363546513518416
  • 18. Akşahin, Ertuğrul, et al. “The comparison of the effect of corticosteroids and platelet-rich plasma (PRP) for the treatment of plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.6 (2012): 781-785.
  • 19. Ragab, Ehab Mohamed Selem, and Ahmed Mohamed Ahmed Othman. “Platelets rich plasma for treatment of chronic plantar fasciitis.” Archives of orthopaedic and trauma surgery 132.8 (2012): 1065-1070.
  • 20. Doaa H. Ibrahim, Nagat M. El-Gazzar, Hanan M. El-Saadany, Radwa M. El-Khouly, Ultrasound-guided injection of platelet rich plasma versus corticosteroid for treatment of rotator cuff tendinopathy: Effect on shoulder pain, disability, range of motion and ultrasonographic findings. The Egyptian Rheumatologist, Volume 41, Issue 2, 2019, Pages 157-161, ISSN 1110-1164, https://doi.org/10.1016/j.ejr.2018.06.004.
  • 21. Dadgostar, H., Fahimipour, F., Pahlevan Sabagh, A. et al. Corticosteroids or platelet-rich plasma injections for rotator cuff tendinopathy: a randomized clinical trial study. J Orthop Surg Res 16, 333 (2021). https://doi.org/10.1186/s13018-021-02470-x
  • 22. Begkas D, Chatzopoulos ST, Touzopoulos P, Balanika A, Pastroudis A. Ultrasound-guided Platelet-rich Plasma Application Versus Corticosteroid Injections for the Treatment of Greater Trochanteric Pain Syndrome: A Prospective Controlled Randomized Comparative Clinical Study. Cureus. 2020;12(1):e6583. Published 2020 Jan 7. doi:10.7759/cureus.6583
  • 23. ROSÁRIO, DAVI ARAÚJO VEIGA et al. COMPARISON BETWEEN CONCENTRATED BONE MARROW ASPIRATE AND CORTICOID IN GLUTEAL TENDINOPATHY. Acta Ortopédica Brasileira [online]. 2021, v. 29, n. 1 [Accessed 1 December 2021] , pp. 26-29. Available from: <https://doi.org/10.1590/1413-785220212901236828>. Epub 10 Mar 2021. ISSN 1809-4406. https://doi.org/10.1590/1413-785220212901236828.
  • 24. Tang, J.Z., Nie, M.J., Zhao, J.Z. et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res 15, 403 (2020). https://doi.org/10.1186/s13018-020-01919-9