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NAD and NAD+ occur naturally in the body. They play a major role in the chemical process of generating energy. NAD+ is probably the most important cofactor for improving mitochondrial function. Mitochondria are the energy powerhouses of almost all living cells where micronutrients are converted to energy-rich ATP molecules for the cell.
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NAD+ is the second most popular cofactor in the human body. Anti-aging therapies are becoming more mainstream as aging is now being viewed as a disease. Now that this transition is happening, the ability for NAD+ to activate PARPS, Sirtuins, and help with immune dysregulation has been thoroughly investigated and NAD+ and its precursors have been highly popularized (3).
The clinical importance of maintaining cellular NAD+ levels was established early in the last century with the finding that pellagra, a disease characterized by diarrhea, dermatitis, dementia and death, could be cured with foods containing the NAD+ precursor niacin. Additionally, cellular concentrations of NAD+ have been shown to decrease under conditions of increased oxidative damage such as occur during aging (2).
Altered levels of NAD+ have been found to accompany several disorders associated with increased oxidative/free radical damage including diabetes, heart disease, age-related vascular dysfunction, ischemic brain injury, misfolded neuronal proteins, and Alzheimer’s dementia (1,2).
Interventions targeted at restoring NAD+ have been shown in animal models to support healthy aging and improve metabolic function, and dementia as well (5).
Benefits of NAD
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Studies show improved pain relief, at least for the first 6 months when compared to cortisone injection – a safer alternative to a cortisone injection.
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