NAD and NAD+ occur naturally in the body. They play a major role in the chemical process of generating energy. NAD+ is probably the most important cofactor for improving mitochondrial function. Mitochondria are the energy powerhouses of almost all living cells where micronutrients are converted to energy-rich ATP molecules for the cell.

NAD+ is the second most popular cofactor in the human body. Anti-aging therapies are becoming more mainstream as aging is now being viewed as a disease. Now that this transition is happening, the ability for NAD+ to activate PARPS, Sirtuins, and help with immune dysregulation has been thoroughly investigated and NAD+ and its precursors have been highly popularized.

The clinical importance of maintaining cellular NAD+ levels was established early in the last century with the finding that pellagra, a disease characterized by diarrhea, dermatitis, dementia, and death, could be cured with foods containing the NAD+ precursor niacin. Additionally, cellular concentrations of NAD+ have been shown to decrease under conditions of increased oxidative damage that occurs during aging.

Altered levels of NAD+ have been found to accompany several disorders associated with increased oxidative/free radical damage including diabetes, heart disease, age-related vascular dysfunction, ischemic brain injury, misfolded neuronal proteins, and Alzheimer’s dementia.

Interventions targeted at restoring NAD+ have been shown in animal models to support healthy aging and improve metabolic function, and dementia as well (5).

Benefits of NAD :

  • Helps repair blood vessels
  • May improve muscle health
  • May help repair cells and DNA
  • May improve cognitive function
  • May help with age-related weight gain